miR?148a controls metabolic programming and survival of mature CD19?negative plasma cells in mice

P-7: Testosterone and Gonadotrophin Hormones Plasma Concentration-Induced Changes in Sertoli and Leydig Cells Number in Hyperprolactinemic Mature Male Mice

Background: Hyperprolactinemia is a particular concern in the treatment of schizophrenic patients. The side effects associated with high prolactin levels can have a negative impact on GnRH pulsatile secretion and, consequently LH, FSH and testosterone pulsatility and follows by, on special testicular cells that have these hormon’s receptors such as sertoli and leydig cells. Quantification the d...

Programming plasma cell survival

744 INSIGHTS | The Journal of Experimental Medicine In this issue, two independent groups show that the transcription factor ZBTB20 is required for the maintenance of long-lived plasma cells following immunization with the commonly used adjuvant, alum. Intriguingly, one group found that ZBTB20 was dispensable for plasma cell survival when they used adjuvants that activate Toll-like receptors (T...

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 ...

Cells in Mice Basophils Support the Survival of Plasma

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

An effective immune system depends upon the survival of mature T cells in the periphery. Members of the GIMAP family of GTPases have been proposed to regulate this homeostasis, supported by the paucity of peripheral T cells in rodents deficient for either GIMAP1 or GIMAP5. It is unclear whether this lack of T cells is a consequence of an ontological defect, causing the thymus to generate and ex...